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The presence of non-responders to GLP-1R therapy continues to complicate treatment outcomes, underscoring the need for a deeper understanding of individual variability in response [117,118]
[22] Peptides with pharmacological activity intended for human use including growth hormone secretagogues are likely to be classified as POMs by default if they were licensed, and their unlicensed supply for human use is therefore unlawful
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Directly activating GIPR in hepatocytes is an unlikely explanation for the decrease in apoC-III levels with tirzepatide [91, 92]
